| Ben Earwood (inactive) | | 1-0-0 | United States | Nov 17, 2000 |
| Cody East (inactive) | The Freight Train | 0-2-0 | United States | Oct 1, 2016 |
| Marvin Eastman (inactive) | The Beastman | 1-4-0 | United States | Jun 21, 2008 |
| Mike Easton (inactive) | The Hulk | 3-4-0 | United States | Jun 14, 2014 |
| Brian Ebersole (inactive) | Bad Boy | 5-3-0 | United States | Jun 6, 2015 |
| Mark Eddiva (inactive) | | 1-3-0 | Philippines | Mar 19, 2016 |
| Frankie Edgar (inactive) | The Answer | 18-11-1 | United States | Nov 12, 2022 |
| Abdul-Kerim Edilov (inactive) | | 1-0-0 | Russia | Sep 2, 2017 |
| Johnny Eduardo (inactive) | | 3-5-0 | Brazil | Oct 2, 2021 |
| Christian Edwards | Pain | 1-1-0 | United States | Sep 26, 2026 |
| Joselyne Edwards | La Pantera | 9-4-0 | Panama | Apr 25, 2026 |
| Justin Edwards (inactive) | Fast Eddy | 2-5-0 | United States | Jun 6, 2015 |
| Leon Edwards | Rocky | 14-5-0 (1 NC) | Jamaica | Nov 15, 2025 |
| Te Edwards (inactive) | | 0-2-0 | United States | Jan 19, 2019 |
| Yves Edwards (inactive) | | 10-10-0 (1 NC) | Bahamas | Nov 22, 2014 |
| Tom Egan (inactive) | | 0-1-0 | Ireland | Jan 17, 2009 |
| Stephanie Egger (inactive) | | 3-4-0 | Switzerland | Dec 9, 2023 |
| Justin Eilers (inactive) | The Hammer | 1-3-0 | United States | Feb 4, 2006 |
| Jon Olav Einemo (inactive) | The Viking | 0-2-0 | Norway | Jan 28, 2012 |
| Per Eklund (inactive) | | 1-2-0 | Sweden | Feb 21, 2009 |
| Evan Elder | The Phenom | 3-2-0 | United States | Apr 26, 2025 |
| Billy Elekana | Son of Susie | 3-1-0 | United States | Jan 31, 2026 |
| Darren Elkins (inactive) | The Damage | 19-12-0 | United States | Aug 8, 2026 |
| Jake Ellenberger (inactive) | The Juggernaut | 10-11-0 | United States | Aug 25, 2018 |
| Joe Ellenberger (inactive) | Excalibur | 1-1-0 | United States | Dec 13, 2014 |
| Ezra Elliott | | 1-0-0 | Unknown | Jul 18, 2026 |
| Oban Elliott | The Welsh Gangster | 3-3-0 | United Kingdom | Aug 1, 2026 |
| Tim Elliott | | 11-12-0 | United States | Sep 12, 2026 |
| Lisa Ellis (inactive) | | 0-2-0 | United States | May 9, 2015 |
| Elisha Ellison | The Snack Panther | 0-2-0 | United States | Jul 11, 2026 |
| Anna Elmose (inactive) | Panda | 0-2-0 | Denmark | Nov 19, 2016 |
| Cameron Else (inactive) | Camchida | 0-2-0 | United Kingdom | Apr 23, 2022 |
| Ramazan Emeev (inactive) | Gorets | 5-3-0 | Russia | Jun 11, 2022 |
| Rob Emerson (inactive) | The Saint | 3-3-0 (1 NC) | United States | Mar 31, 2010 |
| Jamall Emmers | Pretty Boy | 6-4-0 | United States | Aug 22, 2026 |
| Josh Emmett | | 10-7-0 | United States | Mar 14, 2026 |
| Oliver Enkamp (inactive) | | 0-2-0 | Sweden | Mar 17, 2018 |
| Ian Entwistle (inactive) | Enty | 1-2-0 | United Kingdom | Apr 10, 2016 |
| Andy Enz (inactive) | Tank Mode | 0-3-0 | United States | Jan 31, 2015 |
| Steve Erceg | Astroboy | 5-4-0 | Australia | Jul 25, 2026 |
| Konstantin Erokhin (inactive) | | 0-2-0 | Russia | Dec 11, 2015 |
| Julian Erosa | Juicy J | 9-9-0 | United States | Mar 28, 2026 |
| Jarno Errens (inactive) | | 1-3-0 | Netherlands | Aug 10, 2024 |
| Ivan Erslan (inactive) | | 1-3-0 | Croatia | May 16, 2026 |
| Cole Escovedo (inactive) | Apache Kid | 0-3-0 | United States | Nov 12, 2011 |
| Efrain Escudero (inactive) | Hecho En Mexico | 5-7-0 | Mexico | Apr 23, 2016 |
| Carla Esparza (inactive) | Cookie Monster | 10-6-0 | United States | Oct 5, 2024 |
| Juan Espino (inactive) | El Guapo | 2-1-0 | Spain | Apr 17, 2021 |
| Jordan Espinosa (inactive) | The Gamer | 2-4-0 | United States | Mar 6, 2021 |
| Jodie Esquibel (inactive) | | 0-4-0 | United States | Aug 17, 2019 |
| Rafael Estevam | Macapa | 3-1-0 | Brazil | Apr 4, 2026 |
| Terry Etim (inactive) | | 6-5-0 | United Kingdom | Feb 16, 2013 |
| Fred Ettish (inactive) | | 0-1-0 | United States | Mar 11, 1994 |
| Sijara Eubanks (inactive) | SarJ | 5-5-0 | United States | Dec 18, 2021 |
| Doug Evans (inactive) | | 0-2-0 | United States | Dec 29, 2007 |
| Rashad Evans (inactive) | Suga | 14-8-1 | United States | Jun 9, 2018 |
| Ashlee Evans-Smith (inactive) | Rebel Girl | 3-6-0 | United States | Jul 15, 2023 |
| Dan Evensen (inactive) | The Viking | 0-2-0 | Norway | Dec 27, 2008 |
| Tonya Evinger (inactive) | Triple Threat | 0-3-0 | United States | Jun 1, 2019 |
| Movsar Evloev | | 10-0-0 | Russia | Mar 21, 2026 |
| Andre Ewell (inactive) | Mr. Highlight | 4-5-0 | United States | Dec 18, 2021 |
| Ethyn Ewing | The Professor Finesser | 2-0-0 | United States | Apr 4, 2026 |
| Jessica Eye (inactive) | Evil | 5-10-0 (1 NC) | United States | Jul 2, 2022 |